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Project TitleBiodegradable Photo-Crosslinked Micellar Platformfor Drug Delivery
Track Code7522
Short Description

A micelle composed of a biodegradable pseudo-protein polymer with photo-controllable crosslinking sites for the delivery of therapeutics.

Abstract

Targeted drug delivery can be enhanced by encapsulating therapeutic drugs in polymer based micelles. In the present invention, modulation and functionalization of the micelle polymer offers a pathway to control drug release and the impact of intracellular stimuli (e.g. pH, enzyme presence, electrochemical potential).

 

These newly developed nanometer sized micelles are composed of a pseudo-protein polymer backbone, allowing for a high degree of biocompatibility. A photo-controllable functional group permits crosslinking of the polymer, dramatically enhancing structural stability. The crosslinked micelles are resistant to dilution-induced micelle disintegration. In-vitro release studies show that delivery of the chemotherapeutic drug, doxorubicin (DOX), is not hindered by the crosslinking. Release of DOX is in-fact accelerated by enzymatic biodegradation of the pseudo-protein backbone which occurs within the targeted HCT116 colon cancer cells.

 

Potential Applications

· Drug Delivery

· Targeted Chemotherapy

 

Advantages

· Enhance bioavailability of drug molecule

· Improved stability under physiological conditions

· Photochemical crosslinking of the polymer inhibits premature diffusion of drug out of the micelle

· Biodegradable polymer show excellent biocompatibility

· Synthetically reproducible

 
Tagsanticancer, biocompatible, biodegradable, cancer, chemotherapeutic, chemotherapy, drug delivery, HCT116, micelle, doxorubicin, photocrosslinked, tumor
 
Posted DateJun 27, 2017 10:56 AM

Researcher

Name
Chih-Chang Chu
Ying Ji

Additional Information

A Novel Pseudo-Protein-Based Biodegradable Nanomicellar Platform for the Delivery of Anticancer Drugs. Ying Ji, et.al., Small 2016 13 (1) 1601491.

Licensing Contact

Martin Teschl, Technology Commercialization & Liaison Officer
mt439@cornell.edu
(607) 254-4454

Files

File Name Description
7522-Tech-Brief.pdf None Download
D-7522 Flintbox Image.png None Download