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Project TitleBranched Arginine Based Poly(Ester Urea Urethane) Nanoparticles as Drug Delivery (Chemotherapeutic) Vehicles
Track Code7531
Short Description

Self-assembled nanoparticles (NPs) composed of linear and branched Arginine-based poly-ester urea urethanes (Arg-PEUUs) as carriers for cancer treatments.

Abstract

These self-assembled nanoparticles are easily prepared by a facile dialysis method. Their assembly is directed by a combination of hydrophobic/hydrophilic interactions. By varying the ratio of polymer as well as varying functional groups, the size of the nanoparticles (100-300 nm) as well as their mechanical and hydrophobic properties can be finely tuned. Likewise, photoactive groups suitable for crosslinking can be included to further enhance nanoparticle stability. Even prior to drug loading these nanoparticles enhance macrophage production of TNF-α and nitric oxide.

 

These nanoparticles can be loaded with a variety of chemotherapeutic agents including doxorubicin (DOX) and gambogic acid (GA). In vitro studies performed with GA-loaded nanoparticles, a low solubility chemotherapeautic, showed 80-90% release within 60h. Additional studies show that external folate functionalization can be added to the nanoparticle to enhance cell attachment and facilitate internalization thereby improving the anti-cancer drug potency. Further in vivo studies on MCF-7 (invasive breast ductal carcinoma) xenograft mice show promising results.

  

Potential Applications

· Drug Delivery

· Targeted Chemotherapy

 

Advantages

· Can be neutral or cationic allowing various methods of introduction into targeted cell.

· Can be used in 3D-printing. (Dissolvable in low boiling solvents)

· High degree of biocompatibility and biodegradability in mammalian cells

· Prepared by a facile dialysis method

 

 

 
Tags3D printing, chemotherapeutic, chemotherapy, drug delivery, gambogic acid, micelle, nanoparticle, nanomedicine, pharmaceutical
 
Posted DateJun 27, 2017 10:23 AM

Researcher

Name
Chih-Chang Chu
Mingyu He
Ying Ji

Additional Information

1) Self-Assembled Cationic Biodegradable Nanoparticles from pH Responsive Amino-Acid-Based Poly(Ester Urea Urethane)s and Their Application As a Drug Delivery Vehicle. Mingyu He et.al. Biomacromolecules 2016, 17, 523−537.

2) Folate-decorated arginine-based poly(ester urea urethane) nanoparticles as carriers for gambogic acid and effect on cancer cells. He M, Ro L, Liu J, Chu C-C. J. Biomed. Mater. Res., 2017, 105, 475-490.

Licensing Contact

Martin Teschl, Technology Commercialization & Liaison Officer
mt439@cornell.edu
(607) 254-4454

Files

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7531-Tech-Brief.pdf None Download
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