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Project TitleSingle Molecule Epigenetic Analysis in Nanofluidic Channels
Track Code4823
Short Description

A new method and device were developed for identifying epigenetic modifications to chromosomes.

Abstract

While it has been realized that epigenetic modifications have profound effects on cell development and disease conditions, current methods used to obtain epigenetic information are slow, require genetic material from many thousands of cells, and query only one epigenetic modification at a time. The novel Cornell method involves a unique nanofluidic device that will allow information about multiple epigenetic marks to be obtained simultaneously and more rapidly from small samples, using a single-molecule analytical method. The device isolates individual molecules of DNA or chromatin and optically identifies labels indicating the existence of a specific epigenetic state. A multiplexed format will further permit searching for the existence of many epigenetic conditions, simultaneously, in a single sample.

                       

Potential Applications

  • Epigenetic research, particularly epigenomic profiling and mapping

 

Advantages

  • Multiple mark information obtained simultaneously
  • Rapid analysis of very small samples
  • Multiplexed format
 
TagsDNA-RNA Tools, Genetic Screening, life science, physical science, molecular diagnostics, microfluidics
 
Posted DateJul 20, 2012 7:21 PM

Researcher

Name
Paul Soloway
Benjamin Cipriany
Harold Craighead
Stephen Levy

Additional Information

Licensing Contact

Martin Teschl
mt439@cornell.edu
(607) 254-4454